Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived From Ten Colombian Plants
Identifieur interne : 000E55 ( Main/Exploration ); précédent : 000E54; suivant : 000E56Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived From Ten Colombian Plants
Auteurs : Jf Sanchez-Suarez [Colombie] ; I. Riveros [Colombie] ; G. Delgado [Colombie]Source :
- Iranian Journal of Parasitology [ 1735-7020 ] ; 2013.
Abstract
The leishmanicidal and cytotoxic activity of ten essential oils obtained from ten plant specimens were evaluated.
Essential oils were obtained by the steam distillation of plant leaves without any prior processing. Cytotoxicity was tested on J774 macrophages and leishmanicidal activity was assessed against four species of
Seven essential oils exhibited activity against
The essential oil of
Url:
PubMed: 23682270
PubMed Central: 3655250
Affiliations:
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<country xml:lang="fr">Colombie</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of the Leishmanicidal and Cytotoxic Potential of Essential Oils Derived From Ten Colombian Plants</title>
<author><name sortKey="Sanchez Suarez, Jf" sort="Sanchez Suarez, Jf" uniqKey="Sanchez Suarez J" first="Jf" last="Sanchez-Suarez">Jf Sanchez-Suarez</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Immunotoxicology Research Group, Dept. of Pharmacy. Faculty of Sciences, Universidad Nacional de Colombia, Bogotá, Colombia</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Immunotoxicology Research Group, Dept. of Pharmacy. Faculty of Sciences, Universidad Nacional de Colombia, Bogotá</wicri:regionArea>
<wicri:noRegion>Bogotá</wicri:noRegion>
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<author><name sortKey="Riveros, I" sort="Riveros, I" uniqKey="Riveros I" first="I" last="Riveros">I. Riveros</name>
<affiliation wicri:level="1"><nlm:aff id="AF0002">Green Andina LTDA, Bogotá, Colombia</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Green Andina LTDA, Bogotá</wicri:regionArea>
<wicri:noRegion>Bogotá</wicri:noRegion>
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<author><name sortKey="Delgado, G" sort="Delgado, G" uniqKey="Delgado G" first="G" last="Delgado">G. Delgado</name>
<affiliation wicri:level="1"><nlm:aff id="AF0001">Immunotoxicology Research Group, Dept. of Pharmacy. Faculty of Sciences, Universidad Nacional de Colombia, Bogotá, Colombia</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Immunotoxicology Research Group, Dept. of Pharmacy. Faculty of Sciences, Universidad Nacional de Colombia, Bogotá</wicri:regionArea>
<wicri:noRegion>Bogotá</wicri:noRegion>
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<series><title level="j">Iranian Journal of Parasitology</title>
<idno type="ISSN">1735-7020</idno>
<idno type="eISSN">2008-238X</idno>
<imprint><date when="2013">2013</date>
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<front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background</title>
<p>The leishmanicidal and cytotoxic activity of ten essential oils obtained from ten plant specimens were evaluated.</p>
</sec>
<sec id="st2"><title>Methods</title>
<p>Essential oils were obtained by the steam distillation of plant leaves without any prior processing. Cytotoxicity was tested on J774 macrophages and leishmanicidal activity was assessed against four species of <italic>Leishmania</italic>
associated with cutaneous leishmaniasis.</p>
</sec>
<sec id="st3"><title>Results</title>
<p>Seven essential oils exhibited activity against <italic>Leishmania</italic>
parasites, five of which were toxic against J774 macrophages. Selectivity indices of >6 and 13 were calculated for the essential oils of <italic>Ocimum basilicum</italic>
and <italic>Origanum vulgare</italic>
, respectively.</p>
</sec>
<sec id="st4"><title>Conclusion</title>
<p>The essential oil of <italic>Ocimum basilicum</italic>
was active against promastigotes of <italic>Leishmania</italic>
and innocuous to J774 macrophages at concentrations up to 1600 µg/mL and should be further investigated for leishmanicidal activity in others <italic>in vitro</italic>
and <italic>in vivo</italic>
experimental models.</p>
</sec>
</div>
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</back>
</TEI>
<affiliations><list><country><li>Colombie</li>
</country>
</list>
<tree><country name="Colombie"><noRegion><name sortKey="Sanchez Suarez, Jf" sort="Sanchez Suarez, Jf" uniqKey="Sanchez Suarez J" first="Jf" last="Sanchez-Suarez">Jf Sanchez-Suarez</name>
</noRegion>
<name sortKey="Delgado, G" sort="Delgado, G" uniqKey="Delgado G" first="G" last="Delgado">G. Delgado</name>
<name sortKey="Riveros, I" sort="Riveros, I" uniqKey="Riveros I" first="I" last="Riveros">I. Riveros</name>
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</affiliations>
</record>
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